Emerging role of HMGB 1 in fibrotic diseases
نویسندگان
چکیده
منابع مشابه
Emerging role of Twist1 in fibrotic diseases
Epithelial-mesenchymal transition (EMT) is a pathological process that occurs in a variety of diseases, including organ fibrosis. Twist1, a basic helix-loop-helix transcription factor, is involved in EMT and plays significant roles in various fibrotic diseases. Suppression of the EMT process represents a promising approach for the treatment of fibrotic diseases. In this review, we discuss the r...
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High-mobility group box 1 (HMGB1) is originally identified as a DNA-binding protein that functions as a structural co-factor critical for proper transcriptional regulation in somatic cells. Recent studies indicate that HMGB1 can be passively released from necrotic cells or actively secreted into the extracellular milieu under appropriate signal stimulation. Extracellular HMGB1 is a multifunctio...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2014
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.12419